Congenital and Juvenile Hypothyroidism Due to Thyroid Dysgenesis.
نویسندگان
چکیده
Following the initial description of an ectopic thyroid by Verneuil, ( 1 ) it remained only as an anatomical curiosity for many years. Hunt ( 2 ) described dysphagia and obstruction of the upper larynx caused by a lingual thyroid and suggested the clinical importance of this entity. Mont gomery ( 3 ) has reviewed most of the reported cases, and observed that surgi cal ablation of the ectopic tissue was followed by hypothyroidism (4). With the use of radioiodine in the diagnosis of thyroid disease, more than 300 cases of ectopic tissue had been described by 1956, most of them having clinical symptoms related to impaired respiration or swallowing (5). The first functional approach to the problem of ectopic thyroid tissue was made by McGirr and Hutchinson ( 6 ) , who reported two cases associated with myxedema and cretinism. A tracer dose of radioiodine revealed that most of the labeled iodide was present in the base of the tongue. The cause of myxedema in these patients was the failure of the ectopic thyroid to maintain physiological levels of thyroid hormones in the plasma. Kellershohn and his associates (7) reported that 60 per cent of 23 children with congenital hypothyroidism had evidence of ectopic thyroid. Other reports (8-9) seem to confirman elevatedincidenceof thisanomaly in childrenor adolescents with hypothyroidism. The present paper reports the clinical and laboratory observations and the progress of thirteen patients with thyroid remnants studied at the Hospital das Clinicas, University of Sao Paulo Medical School in cooperation with the Atomic Energy Institute.
منابع مشابه
Lingual Thyroid: A Case Report and Literature Review
Thyroid ectopia is a dysgenesis of thyroid gland and Lingual position represents the most frequent ectopic location accounting up to 90% of ectopic cases. Hypothyroidism is commonly present because of absence of a normal thyroid gland in most instances. Primary hypothyroidism in juvenile population generally leads to retardation of linear growth and delay or even arrested puberty. We present a ...
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2/17 Clinical Features: Congenital hypothyroidism is a condition characterized by inadequate availability of active thyroid hormone to target tissues in the newborn period. It can be sporadic or inherited. In 80 to 85% of cases, congenital hypothyroidism is the consequence of thyroid dysgenesis due to absent (athyreosis), abnormally located (ectopic), or small (hypoplastic) thyroid gland (1). C...
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عنوان ژورنال:
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
دوره 6 شماره
صفحات -
تاریخ انتشار 1965